Severely damaged organs due to primary injury or due to shock with pro­longed hypotension lasting longer than 30 minutes.

Serum creatinine remains more than 2.5 mg/dl even after rehydration.  Neurosurgical patients are often dehydrated because of procedures carried out to reduce brain edema such as use of lasix and mannitol.  The organ from such a patient may not be suitable for donation.  However, the National Kidney Foundation must be consulted before deciding not to harvest.

Long standing renal disease and/or severe uncontrolled hypertension.  However, patients with mild diabetes mellitus or mild systemic lupus erythematosus may be accepted as donors.

Virus infections such as HIV, Hepatitis B etc.  Organs from patients who are HBsAg positive may be accepted, and given to recipients who are HBsAg positive, but those without active disease.  In some instances, patients who are thought to be immune to Hepatitis B either primarily or by vaccination may also be considered as recipients.  This is to be decided on a case-to-case basis.

Organs from patients who have positive CMV should be given only to CMV positive recipients.

An age of (i) less than two years or (ii) more than 65 years.  However, in some cases, exceptions can be made.  Check with NKF regarding their acceptability.  When the age is not known, a decision should be made considering the general condition of the patient, history of hypertension, serum creatinine, etc.  Anencephalic newborns are not acceptable as donors.

Known or suspected malignant tumors, except those with primary brain tumor and primary malignancy of the skin.