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Technical
facilities required
The hospital in which the heart transplant center will be
established should include:
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Departments
of Gastroenterology, Radiology, Hematology,
Pathology, laboratory, Biochemical laboratory,
Nephrology with hemodialysis unit and Immunology.
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At
least two fully equipped open-heart surgical
theaters equipped with circulatory support systems,
e.g., intra-aortic balloon pump, by-pass support
systems or mechanical assist devices with the
availability of technicians necessary to handle
them. -- A fully equipped ICU should be available
for management of patients after open-heart surgery
with facilities to isolate patients as well as
installation of pacemakers, both temporary and
permanent.
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- The
following specialists should be available in the hospital
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Fully
certified Nephrologists experienced in the follow-up
of organ transplant recipients.
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Immunologists
experienced in follow-up of heart transplantation.
- Certified
pulmonologist.
- Certified
respiratory therapists
- Certified
infectious disease specialist.
- Team
for infection control.
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Certified
pathologists with experience in interpreting
myocardial biopsies.
- Certified
psychiatrist.
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Indications
for heart transplantation
The
Saudi Center for Organ Transplantation through its scientific
committees has laid down indications for heart transplantation
in the Kingdom as follows:
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First:
All patients who have end-stage cardiac disease
unresponsive to adequately supervised medical
therapy and not amenable to any currently acceptable
medical or surgical treatment. (left ventricular
ejection fraction less than 20%).
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Second:
Patient should be categorized in NYHA functional
class III-IV.
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Third:
Patient having unresectable cardiac tumors.
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Fourth:
Patients who fail to come off
cardio-pulmonary bypass.
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Fifth:
Patient that are dying from acute myocardial
infarction.
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Contra-indications
for heart transplantation
Absolute Contra-indications:
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Age
more than 55 years.
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High
pulmonary vascular resistance of more than 6 wood
units despite intensive cardiac management.
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Malignancy.
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Collagen
vascular disease.
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Renal
failure above and beyond the expected pre-renal
failure.
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Hepatic
failure which exceeds that explained by cardiac
failure or when accompanied by significant
coagulopathy.
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Other
irreversible organ diseases such as emphysema,
intractable systemic illness or amyloidosis.
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Patients
who are emotionally unstable or irresponsible and
who have psychological abnormalities, and cannot
cope with the demands and burdens of strict
compliance with medications and follow-up
requirements.
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Infection
with HIV.
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History
of substance abuse (alcohol or other drugs).
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Relative
contra-indications *
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Diabetes
mellitus, especially type I.
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Peptic
ulcer disease.
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Unresolved
pulmonary infarction.
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Marked
obesity.
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Cachexic
patients.
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History
of CMV, EBV, toxoplasmosis, sickle cell disease, or
thyroid dysfunction.
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Uncontrolled
hypertension.
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Presence
of active systemic infection.
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*
Patients with positive PPD or clinical evidence tuberculosis
are to be treated prophylactically with INH for 12 months.
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Priority
criteria for heart transplantation
The Saudi Center for Organ Transplantation through
its scientific committees has laid down priority criteria for
heart transplantation as follows:
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Priority
1. Patients on mechanical cardiac
support or on ventilator or cannot be weaned off
inotropic support or those who fail to come off
cardio-pulmonary bypass.
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Priority
2. Patients who require inotropic
support, with no requirement for ventilation or
mechanical cardiac support.
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Priority
3. Patients who are on the waiting list
and are waiting at home.
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Distribution
of hearts
The harvested heart is distributed as follows:
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Each
heart transplant center should establish a local
waiting list, which should be sent to the Saudi
Center for Organ Transplantation so that a national
waiting list could be made according to priority
criteria. The heart transplant center could change
the patient’s priority level between the
previously mentioned categories according to the
patient’s condition, after informing the Saudi
Center for Organ Transplantation about this.
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All
transplant centers should inform the Saudi Center
for Organ Transplantation about patients who need
urgent heart transplantation so that they can be put
in a special urgent waiting list in Saudi Center for
Organ transplantation.
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Patients
in the urgent waiting list have the absolute
priority wherever they are, because patients on
priority I do not follow the rota system.
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If
there is no suitable patient* in the urgent waiting
list, the heart will be transplanted in the heart
transplant center according to the rota. If the
center does not have a suitable patient, the heart
will be given to the center which has a suitable
patient in which case the selection of the patient
will be according to blood group and the date from
which the patient is registered in the local waiting
list.
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*
A suitable patient is one who fulfills medical fitness and
priority criteria.
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